rs17563

A SNP in the BMP4 gene on chromosome 14. Its most notable genotype is G;G: Risk for otosclerosis

Gene
BMP4
Location
Chr 1453,950,804 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadRisk for otosclerosisWorth knowing · 2.111% of people
  2. A;AGoodcommon in clinvarTypical · 0.048% of people

SNPedia records rs17563 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 11% A;A 48%
  • European ancestry (Utah)G;G 37% A;A 16%
  • Han Chinese (Beijing)G;G 8% A;A 47%
  • Japanese (Tokyo)G;G 6% A;A 57%
  • Yoruba (Nigeria)G;G 2% A;A 72%
  • African ancestry (Southwest US)G;G 5% A;A 61%
  • Chinese (Denver)G;G 8% A;A 55%
  • Gujarati IndianG;G 7% A;A 43%
  • Luhya (Kenya)G;G 6% A;A 59%
  • Mexican ancestry (Los Angeles)G;G 10% A;A 45%
  • Maasai (Kenya)G;G 6% A;A 46%
  • TuscanG;G 26% A;A 28%

Notes

From SNPedia

Notes

rs17563(G) allele, coding for the amino acid alanine, confers susceptibility to otosclerosis (combined populations: p = 0.002; OR = 1.209; 95% CI: 1.070-1.370)

Source and license

Adapted from rs17563 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.