rs17580(A;A)

A slightly reduced functionality form of Alpha-1 Antitrypsin Deficiency

Magnitude
2.5Worth knowing
Repute
Bad
Frequency
0%Average of 4 populations
On SNPedia
rs17580(T;T)Minus strand
Gene
SERPINA1

Frequency

Share of people with A;A in each HapMap population.

  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%

Other genotypes of rs17580

  1. T;TGoodcommon in complete genomicsTypical · 0.098% of people
  2. A;TBadCarrier of one PiS variant; slight chance of Alpha-1 Antitrypsin DeficiencyWorth knowing · 2.33% of people

All about rs17580

Notes

From SNPedia

This variant represents carrying two copies of the PiS variant in alpha-1-antitrypsin deficiency with 60% enzymatic activity. No direct correlation with liver disease according to Liver Disease in Alpha 1-Antitrypsin Deficiency: A Review and no increased risk of emphysema according to omim.org.

Source and license

Adapted from rs17580(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.