rs17646665

A SNP in the SORT1 gene on chromosome 1. Its most notable genotype is G;G: Reduced risk for Alzheimer's (~0.33x?)

Gene
SORT1
Location
Chr 1109,369,429 (GRCh38)
Highest magnitude
4.2Very important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.091% of people
  2. A;GGoodModerately reduced risk for Alzheimer's (~0.6x)Important · 3.99% of people
  3. G;GMost notableGoodReduced risk for Alzheimer's (~0.33x?)Very important · 4.2<1% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 91% A;G 9% G;G <1%
  • European ancestry (Utah)A;A 87% A;G 12% G;G 2%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
  • Japanese (Tokyo)A;A 98% A;G 2% G;G 0%
  • Yoruba (Nigeria)A;A 91% A;G 10% G;G 0%
  • African ancestry (Southwest US)A;A 83% A;G 18% G;G 0%
  • Chinese (Denver)A;A 98% A;G 2% G;G 0%
  • Gujarati IndianA;A 91% A;G 9% G;G 0%
  • Luhya (Kenya)A;A 85% A;G 16% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 91% A;G 9% G;G 0%
  • Maasai (Kenya)A;A 87% A;G 12% G;G 1%
  • TuscanA;A 92% A;G 8% G;G 0%

Notes

From SNPedia

Notes

Minor Allele (G) associated with reduced risk (OR 0.6x, CI: 0.4-0.8) for Alzheimer's Disease; it is possible that the reported association could be restricted to a Swedish/Scandinavian population.

A;G

see link via main rs-page

G;G

see text via main rs-page

Source and license

Adapted from rs17646665 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.