rs1793004

A SNP in the NELL1 gene on chromosome 11. Its most notable genotype is G;G: increased risk for Crohn's disease

Gene
NELL1
Location
Chr 1120,677,383 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
35%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadincreased risk for Crohn's diseaseTypical · 0.040% of people
  2. C;GNot rated?Typical · 0.046% of people
  3. C;CGood0.89x decreased risk for Crohn's diseaseTypical · 0.014% of people

SNPedia records rs1793004 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 40% C;G 46% C;C 14%
  • European ancestry (Utah)G;G 58% C;G 34% C;C 8%
  • Han Chinese (Beijing)G;G 27% C;G 57% C;C 16%
  • Japanese (Tokyo)G;G 18% C;G 52% C;C 30%
  • Yoruba (Nigeria)G;G 37% C;G 52% C;C 11%
  • African ancestry (Southwest US)G;G 45% C;G 41% C;C 14%
  • Chinese (Denver)G;G 24% C;G 53% C;C 23%
  • Gujarati IndianG;G 42% C;G 44% C;C 14%
  • Luhya (Kenya)G;G 48% C;G 40% C;C 12%
  • Mexican ancestry (Los Angeles)G;G 31% C;G 50% C;C 19%
  • Maasai (Kenya)G;G 50% C;G 45% C;C 5%
  • TuscanG;G 55% C;G 44% C;C 1%

Conditions, medicines and genes

Other NELL1 SNPs

All NELL1 SNPs

Notes

From SNPedia

Notes

rs1793004 is a SNP in the NELL1 gene that was found in a genome-wide association study to be associated with Crohn's disease. In several European populations, the most common allele, rs1793004(C), was associated with increased risk for Crohn's disease. Conversely, the odds ratio (pooled over several populations) for the minor allele, rs1793004(G), was 0.89 (CI: 0.69-1.14, p=0.0037).

Source and license

Adapted from rs1793004 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.