rs1799913
A SNP in the TPH1 gene on chromosome 11. Its most notable genotype is G;G: Hispanics may be at increased risk of heroin addiction.
- Gene
- TPH1
- Location
- Chr 1118,025,708 (GRCh38)
- Highest magnitude
- 1.1Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 36%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1799913 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
commonly referred to as A779C Only for Hispanics, individuals who have a genoset composed of rs1799913(C;C) and rs7963720(T;T) are reported to be at 14x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012). Again, only for Hispanics, individuals having a genoset composed of rs1799913(C;C) and rs4290270(T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.5-153, p=0.063). Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach. Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.
G;G
If Hispanics also have rs7963720(T;T) then they have 9x to 14x the risk of heroin addiction.
Source and license
Adapted from rs1799913 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.