rs1799969

A SNP in the LOC105372272 gene on chromosome 19. Its most notable genotype is A;A: slightly higher breast cancer risk

Gene
LOC105372272
Location
Chr 1910,284,116 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedslightly higher breast cancer riskTypical · 0.0<1% of people
  2. A;GNot ratedslightly higher breast cancer riskTypical · 0.09% of people
  3. G;GGoodnormalTypical · 0.091% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageA;A <1% A;G 9% G;G 91%
  • European ancestry (Utah)A;A 0% A;G 20% G;G 80%
  • Han Chinese (Beijing)A;A 0% A;G <1% G;G 99%
  • Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 2% G;G 98%
  • Gujarati IndianA;A 0% A;G 8% G;G 92%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 33% G;G 66%
  • Maasai (Kenya)A;A 0% A;G <1% G;G 99%
  • TuscanA;A 0% A;G 17% G;G 83%

Conditions, medicines and genes

Other LOC105372272 SNPs

All LOC105372272 SNPs

Notes

From SNPedia

Notes

rs1799969, also known as G241R or +241G/A, is a SNP in the ICAM1 gene. The more common (G) allele encodes the glycine (G). A study of 276 Iranian breast cancer patients concluded (p = 0.008) that rs1799969(A) allele carriers may have a higher risk of developing breast cancer.

Source and license

Adapted from rs1799969 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.