rs1799977
A SNP in the MLH1 gene on chromosome 3. Its most notable genotype is A;A: common in clinvar
- Gene
- MLH1
- Location
- Chr 337,012,077 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 17%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 78%
- European ancestry (Utah)A;A 43%
- Han Chinese (Beijing)A;A 94%
- Japanese (Tokyo)A;A 89%
- Yoruba (Nigeria)A;A 95%
- African ancestry (Southwest US)A;A 72%
- Chinese (Denver)A;A 95%
- Gujarati IndianA;A 74%
- Luhya (Kenya)A;A 91%
- Mexican ancestry (Los Angeles)A;A 78%
- Maasai (Kenya)A;A 92%
- TuscanA;A 37%
Related
Other MLH1 SNPs
- rs11541859G;TLynch syndrome, pathogenic mutationVery important
- rs35001569A;TLynch syndrome, pathogenic mutationVery important
- rs41542214C;TLynch syndromeVery important
- rs63749795C;TLynch syndrome, pathogenic mutationVery important
- rs63749804-;CLynch syndrome, pathogenic mutationVery important
- rs63749813-;GALynch syndrome, pathogenic mutationVery important
- rs63749816-;CLynch syndrome, pathogenic mutationVery important
- rs63749818A;CLynch syndrome, pathogenic mutationVery important
Source and license
Adapted from rs1799977 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.