rs1800169

A SNP in the ZFP91-CNTF gene on chromosome 11. Its most notable genotype is A;A: normal

Gene
ZFP91-CNTF
Location
Chr 1158,624,028 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.02% of people
  2. A;GNot ratednormalTypical · 0.019% of people
  3. G;GGoodgreater relative benefit of iloperidone to schizophrenicsTypical · 0.079% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 2% A;G 19% G;G 79%
  • European ancestry (Utah)A;A 4% A;G 22% G;G 74%
  • Han Chinese (Beijing)A;A 2% A;G 25% G;G 74%
  • Japanese (Tokyo)A;A 4% A;G 20% G;G 76%
  • Yoruba (Nigeria)A;A <1% A;G 5% G;G 95%
  • African ancestry (Southwest US)A;A 0% A;G 9% G;G 91%
  • Chinese (Denver)A;A <1% A;G 27% G;G 73%
  • Gujarati IndianA;A 3% A;G 26% G;G 71%
  • Luhya (Kenya)A;A 0% A;G 4% G;G 96%
  • Mexican ancestry (Los Angeles)A;A 3% A;G 38% G;G 59%
  • Maasai (Kenya)A;A <1% A;G 12% G;G 87%
  • TuscanA;A 4% A;G 26% G;G 71%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1800169 is a SNP in the ciliary neurotrophic factor CNTF gene. In a study of 417 patients with schizophrenia, 279 were treated with iloperidone while 138 were treated with placebo. Iloperidone significantly improved in 6 clinical scores versus placebo. rs1800169(G;G) homozygotes showed greater improvement with iloperidone compared to placebo for 3 of the clinical scores compared to carriers of a rs1800169(A) allele.

Source and license

Adapted from rs1800169 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.