rs1800437

A SNP in the GIPR gene on chromosome 19. Its most notable genotype is C;C: average

Gene
GIPR
Location
Chr 1945,678,134 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedaverageTypical · 0.03% of people
  2. C;GBad0.72x risk for heart diseaseTypical · 0.028% of people
  3. G;GNot ratedaverageTypical · 0.069% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 3% C;G 28% G;G 69%
  • European ancestry (Utah)C;C 5% C;G 26% G;G 69%
  • Han Chinese (Beijing)C;C 7% C;G 27% G;G 67%
  • Japanese (Tokyo)C;C 0% C;G 46% G;G 55%
  • Yoruba (Nigeria)C;C 0% C;G 14% G;G 86%

Notes

From SNPedia

Notes

SNP rs1800437, located in the coding region of the GIPR gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele.

Source and license

Adapted from rs1800437 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.