rs1800759

A SNP in the ADH4 gene on chromosome 4. Its most notable genotype is T;T: increased risk for alcohol or drug dependence; increased agreeableness (?)

Gene
ADH4
Location
Chr 499,144,358 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedincreased risk for alcohol or drug dependence; increased agreeableness (?)Typical · 0.029% of people
  2. G;TNot ratednormal; increased agreeableness (?)Typical · 0.035% of people
  3. G;GNot ratednormalTypical · 0.035% of people

SNPedia records rs1800759 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 29% G;T 35% G;G 35%
  • European ancestry (Utah)T;T 14% G;T 48% G;G 38%
  • Han Chinese (Beijing)T;T 6% G;T 32% G;G 62%
  • Japanese (Tokyo)T;T <1% G;T 32% G;G 67%
  • Yoruba (Nigeria)T;T 75% G;T 25% G;G 0%
  • African ancestry (Southwest US)T;T 59% G;T 39% G;G 2%
  • Chinese (Denver)T;T 2% G;T 18% G;G 80%
  • Gujarati IndianT;T 0% G;T 21% G;G 79%
  • Luhya (Kenya)T;T 66% G;T 31% G;G 3%
  • Mexican ancestry (Los Angeles)T;T 28% G;T 59% G;G 14%
  • Maasai (Kenya)T;T 54% G;T 36% G;G 10%
  • TuscanT;T 18% G;T 48% G;G 34%

Other ADH4 SNPs

All ADH4 SNPs

Notes

From SNPedia

Show notes, about 120 words

rs1800759 is a SNP in the promoter (regulatory region) of the alcohol dehydrogenase 4 (ADH4) gene. In a study of 500+ patients with either alcohol dependence or drug dependence, rs1800759 was the most significant ADH4 SNP to be associated (in a recessive manner) with increased risk for either condition, at least in Caucasians. In another study, a five-factor model of personality in 243 subjects with substance dependence (175 European Americans [EAs] and 68 African Americans [AAs]), along with 296 healthy control subjects (256 EAs and 40 AAs), was conducted in association with an ADH4 SNP survey. rs1800759(A) alleles and (A;A) genotypes A/A were significantly associated with agreeableness scores.

Source and license

Adapted from rs1800759 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.