rs1800796
A SNP in the LOC541472 gene on chromosome 7. Its most notable genotype is C;C: slightly increased risk for abdominal aortic aneurysm reported
- Gene
- LOC541472
- Location
- Chr 722,726,627 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 29%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadslightly increased risk for abdominal aortic aneurysm reported
- C;GBadNo summary available.
- G;GGoodcommon in complete genomics
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 34% C;G 21% G;G 45%
- European ancestry (Utah)C;C 0% C;G 8% G;G 92%
- Han Chinese (Beijing)C;C 58% C;G 38% G;G 4%
- Japanese (Tokyo)C;C 75% C;G 23% G;G 2%
- Yoruba (Nigeria)C;C 2% C;G 16% G;G 82%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 220 words
rs1800796 IL-6 572G>C polymorphism (and h.211 haplotype) is associated with abdominal aortic aneurysm (AAA). The risk allele is C. Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure. rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00) rs1800796 coronary artery disease 190 affected Asian Indian sibling pairs
C;C
see discussion at rs1800796
G;G
appears to be common on the 23andMe platform
Source and license
Adapted from rs1800796 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.