rs1805016
A SNP in the IL4R gene on chromosome 16. Its most notable genotype is T;T.
- Gene
- IL4R
- Location
- Chr 1627,363,606 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 12%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageT;T 73%
- European ancestry (Utah)T;T 87%
- Han Chinese (Beijing)T;T 100%
- Japanese (Tokyo)T;T 100%
- Yoruba (Nigeria)T;T 39%
- African ancestry (Southwest US)T;T 35%
- Gujarati IndianT;T 92%
- Luhya (Kenya)T;T 42%
- Mexican ancestry (Los Angeles)T;T 97%
- Maasai (Kenya)T;T 42%
- TuscanT;T 92%
Related
Notes
From SNPedia
Notes
among high-grade glioma cases rs1805016 (TT versus GT/GG) was significantly protective against mortality over time [hazard ratios (HR), 0.59; 95% confidence intervals (CI), 0.40-0.88]. The IL4R rs1805016 and rs1805015 TT genotypes were both found to be significantly associated with survival beyond 1 year among patients with high-grade glioma (HR, 0.44; 95% CI, 0.27-0.73 and HR, 0.63; 95% CI, 0.44-0.91, respectively)
Source and license
Adapted from rs1805016 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.