rs1805124
A SNP in the SCN5A gene on chromosome 3. Its most notable genotype is T;T: common in clinvar
- Gene
- SCN5A
- Location
- Chr 338,603,929 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 21%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1805124 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 63%
- European ancestry (Utah)T;T 65%
- Han Chinese (Beijing)T;T 77%
- Japanese (Tokyo)T;T 75%
- Yoruba (Nigeria)T;T 45%
- African ancestry (Southwest US)T;T 54%
- Chinese (Denver)T;T 85%
- Gujarati IndianT;T 63%
- Luhya (Kenya)T;T 49%
- Mexican ancestry (Los Angeles)T;T 75%
- Maasai (Kenya)T;T 44%
- TuscanT;T 58%
Related
Other SCN5A SNPs
- rs137854606A;CBrugada SyndromeVery important
- rs137854612C;TBrugada SyndromeVery important
- rs137854615A;GBrugada SyndromeVery important
- rs137854620C;TBrugada SyndromeVery important
- rs199473058C;TBrugada SyndromeVery important
- rs199473083C;TBrugada SyndromeVery important
- rs199473225A;GBrugada SyndromeVery important
- rs199473249C;GBrugada SyndromeVery important
Notes
From SNPedia
Notes
rs1805124, also known as His558Arg or H558R, is a SNP in the cardiac sodium channel SCN5A gene. This SNP is quite common, a variants go, with an allele frequency of 10 - 25% in many populations. It seems to be considered to be a benign change.
Source and license
Adapted from rs1805124 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.