rs1805127

A SNP in the KCNE1 gene on chromosome 21. Its most notable genotype is C;T: slight (1.4x) increase in risk for atrial fibrillation

Gene
KCNE1
Location
Chr 2134,449,523 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in clinvarTypical · 0.09% of people
  2. C;TMost notableBadslight (1.4x) increase in risk for atrial fibrillationMinor · 1.443% of people

SNPedia records rs1805127 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 9% C;T 43%
  • European ancestry (Utah)T;T 11% C;T 49%
  • Han Chinese (Beijing)T;T 10% C;T 46%
  • Japanese (Tokyo)T;T 8% C;T 41%
  • Yoruba (Nigeria)T;T 5% C;T 44%
  • African ancestry (Southwest US)T;T 9% C;T 35%
  • Chinese (Denver)T;T 4% C;T 46%
  • Gujarati IndianT;T 9% C;T 46%
  • Luhya (Kenya)T;T 7% C;T 37%
  • Mexican ancestry (Los Angeles)T;T 14% C;T 43%
  • Maasai (Kenya)T;T 3% C;T 33%
  • TuscanT;T 15% C;T 54%

Other KCNE1 SNPs

All KCNE1 SNPs

Notes

From SNPedia

Notes

C;T

see rs1805127

Source and license

Adapted from rs1805127 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.