rs1805129
A SNP in the CHEK2 gene on chromosome 22. Its most notable genotype is T;T: common in complete genomics
- Gene
- CHEK2
- Location
- Chr 2228,734,470 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 4%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1805129 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageT;T 89%
- European ancestry (Utah)T;T 95%
- Han Chinese (Beijing)T;T 87%
- Japanese (Tokyo)T;T 98%
- Yoruba (Nigeria)T;T 83%
- African ancestry (Southwest US)T;T 88%
- Chinese (Denver)T;T 87%
- Gujarati IndianT;T 93%
- Luhya (Kenya)T;T 84%
- Maasai (Kenya)T;T 83%
- TuscanT;T 96%
Related
Other CHEK2 SNPs
- rs121908702A;CBreast cancer associated mutationVery important
- rs137853007A;GBreast cancer associated mutationVery important
- rs587780183-;ABreast cancer associated mutationVery important
- rs587780184-;ABreast cancer associated mutationVery important
- rs587780186-;CBreast cancer associated mutationVery important
- rs587781269A;GBreast cancer associated mutationVery important
- rs587781592A;GBreast cancer associated mutationVery important
- rs587781699C;TBreast cancer associated mutationVery important
Notes
From SNPedia
Notes
This SNP represents a silent polymorphism in the cancer-associated cell cycle regulator CHEK2 gene.
Source and license
Adapted from rs1805129 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.