rs1805388

A SNP in the LIG4 gene on chromosome 13. Its most notable genotype is T;T: reduced risk of multiple myeloma

Gene
LIG4
Location
Chr 13108,211,243 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodreduced risk of multiple myelomaWorth knowing · 2.00% of people
  2. G;GGoodcommon in clinvarTypical · 0.075% of people
  3. A;GGood1.5x reduced risk of multiple myelomaMinor · 1.223% of people

SNPedia records rs1805388 on the minus strand: (A;A), (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 0% G;G 75% A;G 23%
  • European ancestry (Utah)T;T 0% G;G 66% A;G 31%
  • Han Chinese (Beijing)T;T 0% G;G 55% A;G 39%
  • Japanese (Tokyo)T;T 0% G;G 89% A;G 11%
  • Yoruba (Nigeria)T;T 0% G;G 79% A;G 18%
  • African ancestry (Southwest US)T;T 0% G;G 79% A;G 21%
  • Chinese (Denver)T;T 0% G;G 65% A;G 29%
  • Gujarati IndianT;T 0% G;G 85% A;G 14%
  • Luhya (Kenya)T;T 0% G;G 91% A;G 9%
  • Mexican ancestry (Los Angeles)T;T 0% G;G 59% A;G 36%
  • Maasai (Kenya)T;T 0% G;G 81% A;G 18%
  • TuscanT;T 0% G;G 78% A;G 22%

Other LIG4 SNPs

All LIG4 SNPs

Notes

From SNPedia

Notes

T;T

4-fold reduction in risk of developing multiple myeloma omim

A;G

1.5x reduced risk of multiple myeloma omim

Source and license

Adapted from rs1805388 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.