rs1805762
A SNP in the M6PR gene on chromosome 12. Its most notable genotype is G;G: >1.23x risk for hypertension
- Gene
- M6PR
- Location
- Chr 128,945,306 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 10%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1805762 on the minus strand: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 5% C;G 18% C;C 78%
- European ancestry (Utah)G;G 0% C;G 2% C;C 98%
- Han Chinese (Beijing)G;G 7% C;G 29% C;C 64%
- Japanese (Tokyo)G;G 11% C;G 41% C;C 48%
- Yoruba (Nigeria)G;G 0% C;G 0% C;C 100%
Notes
From SNPedia
Notes
rs1805762, a SNP in the M6PR gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, in dbSNP orientation, rs1805762(G), which is also the most common allele, is 1.23 (CI: 1.10 - 1.37, p = 0.0003). A SNP in close linkage, rs1805740, has also been reported in association with hypertension risk in the large 2007 study reported by the Wellcome Trust Consortium.
Source and license
Adapted from rs1805762 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.