rs1816071
A SNP in the GABRB2 gene on chromosome 5. Its most notable genotype is A;G.
- Gene
- GABRB2
- Location
- Chr 5161,332,949 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 36%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1816071 on the minus strand: (T;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;G 0%
- European ancestry (Utah)A;G 0%
- Han Chinese (Beijing)A;G 0%
- Japanese (Tokyo)A;G 0%
- Yoruba (Nigeria)A;G 0%
- African ancestry (Southwest US)A;G 0%
- Chinese (Denver)A;G 0%
- Gujarati IndianA;G 0%
- Luhya (Kenya)A;G 0%
- Mexican ancestry (Los Angeles)A;G 0%
- Maasai (Kenya)A;G 0%
- TuscanA;G 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
Located within intron 8 of the neurotransmitter type A gamma-aminobutyric acid (GABA) A receptor, beta 2 gene, more often as well as officially called GABRB2. This SNP, or more precisely certain haplotypes associated with it, has been linked to schizophrenia, and in particular systematic schizophrenia, in studies on Japanese, Chinese, and German populations PMID 14699426, PMID 16950232. A fascinating and complex argument has been made suggesting that changes in our environment have led to positive selection for the rs1816071(G) containing haplotypes also now seen at increased frequency in schizophrenics . popular in pubmed
Source and license
Adapted from rs1816071 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.