rs182549

A SNP in the MCM6 gene on chromosome 2. Its most notable genotype is C;C: possibly lactose intolerant

Gene
MCM6
Location
Chr 2135,859,184 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadpossibly lactose intolerantWorth knowing · 2.0
  2. C;TGoodCan digest milk.Minor · 1.0
  3. T;TGoodCan digest milk.Minor · 1.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MCM6 SNPs

All MCM6 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 200 words

Also known as "G/A(-22018)" and located in the MCM6 but with influence on the lactase LCT gene, rs182549 is one of two SNPs that is associated with the primary haplotype associated with hypolactasia, more commonly known as lactose intolerance in European Caucasian populations. PMID 11788828, PMID 15114531 In these populations, the rs182549(C) allele (as named in accordance with dbSNP) is both the more common allele and the one associated with lactose intolerance. In populations of sub-Saharan Africans, though, the rs182549(C) allele is unlikely to be predictive of lactose intolerance, and other SNPs are predictive instead. PMID 15106124, PMID 17159977 * See also OMIM 601806.0002 Gender differences in genetic risk profiles for cardiovascular disease. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Ancestry analysis in the 11-M Madrid bomb attack investigation. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

C;C

see also gs100 if you are a caucasian who also has rs4988235(C;C) there is 77% chance of lactose intolerance * See also OMIM 601806.0001

Source and license

Adapted from rs182549 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.