rs1828591

A SNP in the LOC105377462 gene on chromosome 4. Its most notable genotype is G;G: Reduced risk (0.54x) for chronic pulmonary obstructive disease (COPD)

Gene
LOC105377462
Location
Chr 4144,559,628 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.037% of people
  2. A;GGoodReduced risk (0.77x) of chronic obstructive pulmonary disease (COPD)Minor · 1.548% of people
  3. G;GMost notableGoodReduced risk (0.54x) for chronic pulmonary obstructive disease (COPD)Worth knowing · 2.015% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 37% A;G 48% G;G 15%
  • European ancestry (Utah)A;A 38% A;G 45% G;G 17%
  • Han Chinese (Beijing)A;A 47% A;G 45% G;G 9%
  • Japanese (Tokyo)A;A 49% A;G 39% G;G 12%
  • Yoruba (Nigeria)A;A 21% A;G 54% G;G 25%
  • African ancestry (Southwest US)A;A 16% A;G 54% G;G 30%
  • Chinese (Denver)A;A 47% A;G 45% G;G 8%
  • Gujarati IndianA;A 32% A;G 48% G;G 21%
  • Luhya (Kenya)A;A 46% A;G 45% G;G 10%
  • Mexican ancestry (Los Angeles)A;A 40% A;G 56% G;G 4%
  • Maasai (Kenya)A;A 36% A;G 47% G;G 17%
  • TuscanA;A 36% A;G 50% G;G 14%

Notes

From SNPedia

Notes

A genome-wide association study of pulmonary function measures in the Framingham Heart Study. Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.

A;G

see rs1828591

G;G

see rs1828591

Source and license

Adapted from rs1828591 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.