rs1835740

A SNP in the LOC101927066 gene on chromosome 8. Its most notable genotype is T;T: higher risk for migraine in 1 study which has not replicated

Gene
LOC101927066
Location
Chr 897,154,685 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedhigher risk for migraine in 1 study which has not replicatedMinor · 1.016% of people
  2. C;TNot ratedunreplicated, higher risk for migraineMinor · 1.043% of people
  3. C;CGoodnormalTypical · 0.041% of people

SNPedia records rs1835740 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 16% C;T 43% C;C 41%
  • European ancestry (Utah)T;T 4% C;T 37% C;C 58%
  • Han Chinese (Beijing)T;T 34% C;T 48% C;C 18%
  • Japanese (Tokyo)T;T 53% C;T 37% C;C 10%
  • Yoruba (Nigeria)T;T 6% C;T 40% C;C 54%
  • African ancestry (Southwest US)T;T 5% C;T 32% C;C 63%
  • Chinese (Denver)T;T 28% C;T 54% C;C 18%
  • Gujarati IndianT;T 22% C;T 52% C;C 27%
  • Luhya (Kenya)T;T 4% C;T 40% C;C 56%
  • Mexican ancestry (Los Angeles)T;T 3% C;T 38% C;C 59%
  • Maasai (Kenya)T;T 12% C;T 55% C;C 33%
  • TuscanT;T 3% C;T 43% C;C 54%

Notes

From SNPedia

Notes

rs1835740 is a SNP from the 8q22.1 chromosomal region, best known for harboring various genes involved in glutamate metabolism and transport. A large study comprising over 5,000 migraine patients and over 10,000 matched controls, primarily from Europe, found that the rs1835740(A) allele conferred a (slightly) higher risk for the disorder. The reported odds ratio was 1.18, (CI: 1.127–1.244, p = 1.69 × 10e-11).. However this study has failed to replicate in 2 followups.

Source and license

Adapted from rs1835740 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.