rs185386680

A SNP on chromosome 6. Its most notable genotype is A;G: carrier of one HLA-B*38:02:01 allele; avoid thioamide drugs

Gene
None listed
Location
Chr 631,207,153 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.0
  2. A;GMost notableBadcarrier of one HLA-B*38:02:01 allele; avoid thioamide drugsWorth knowing · 2.2

On SNPedia: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

rs185386680(G) appears to be in complete linkage disequilibrium with the HLA-B*38:02:01 allele, and can therefore be used as a marker for it. The HLA-B*38:02:01 allele is associated with carbimazole/methimazole-induced agranulocytosis (OR=265.5, CI: 27.9-2528, p=2.5x10-e14), but not associated with propylthiouracil, so screening for the risk allele may be useful in preventing agranulocytosis in hyperthyroid patients potentially being treated with thioamides antithyroid-drugs, such as thioacetamide, methimazole, or carbimazole.

A;G

see discussion at rs185386680

Source and license

Adapted from rs185386680 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.