rs1859345

A SNP in the SPOCK1 gene on chromosome 5. Its most notable genotype is C;C: slightly earlier age at menarche

Gene
SPOCK1
Location
Chr 5137,111,731 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedslightly earlier age at menarcheTypical · 0.05% of people
  2. C;TNot ratednormalTypical · 0.033% of people
  3. T;TNot ratednormalTypical · 0.062% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 5% C;T 33% T;T 62%
  • European ancestry (Utah)C;C 7% C;T 47% T;T 46%
  • Han Chinese (Beijing)C;C <1% C;T 29% T;T 70%
  • Japanese (Tokyo)C;C 9% C;T 33% T;T 58%
  • Yoruba (Nigeria)C;C 2% C;T 21% T;T 77%
  • African ancestry (Southwest US)C;C 0% C;T 26% T;T 74%
  • Chinese (Denver)C;C 0% C;T 25% T;T 75%
  • Gujarati IndianC;C 9% C;T 52% T;T 40%
  • Luhya (Kenya)C;C 6% C;T 27% T;T 67%
  • Mexican ancestry (Los Angeles)C;C 7% C;T 31% T;T 62%
  • Maasai (Kenya)C;C 5% C;T 27% T;T 69%
  • TuscanC;C 8% C;T 45% T;T 47%

Other SPOCK1 SNPs

All SPOCK1 SNPs

Notes

From SNPedia

Notes

rs1859345 is a SNP in the - get ready - "sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1" SPOCK1 gene. A study of 477 Caucasian women, followed up by replication studies in another ~1,600 and also 1,300+ Chinese women, found that several linked SNPs in the SPOCK1 gene are associated with age at menarche. rs1859345 replicated across all groups studied (p < 10e-3), with the minor (C) allele associated with a (slightly) earlier age at menarche.

Source and license

Adapted from rs1859345 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.