rs1861494
A SNP in the IFNG gene on chromosome 12. Its most notable genotype is C;T: IBD risk
- Gene
- IFNG
- Location
- Chr 1268,157,629 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 27%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;T 35%
- European ancestry (Utah)C;T 52%
- Han Chinese (Beijing)C;T 40%
- Japanese (Tokyo)C;T 30%
- Yoruba (Nigeria)C;T 19%
Related
Notes
From SNPedia
Show notes, about 190 words
Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. A single nucleotide polymorphism (A --> G) in intron 3 of IFNgamma gene is associated with asthma. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.
References
Source and license
Adapted from rs1861494 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.