rs1861973

A SNP in the EN2 gene on chromosome 7. Its most notable genotype is C;C.

Gene
EN2
Location
Chr 7155,461,450 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodNo summary available.Typical · 0.060% of people
  2. T;TGoodcommon in clinvarTypical · 0.05% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 60% T;T 5%
  • European ancestry (Utah)C;C 54% T;T 4%
  • Han Chinese (Beijing)C;C 81% T;T 0%
  • Japanese (Tokyo)C;C 95% T;T 0%
  • Yoruba (Nigeria)C;C 60% T;T 6%
  • African ancestry (Southwest US)C;C 40% T;T 9%
  • Chinese (Denver)C;C 85% T;T 0%
  • Gujarati IndianC;C 46% T;T 8%
  • Luhya (Kenya)C;C 57% T;T 10%
  • Mexican ancestry (Los Angeles)C;C 58% T;T 5%
  • Maasai (Kenya)C;C 37% T;T 10%
  • TuscanC;C 49% T;T 7%

Conditions, medicines and genes

Other EN2 SNPs

All EN2 SNPs

Notes

From SNPedia

Notes

nature The inheritance of the AC haplotype of rs1861972 – rs1861973, the C allele of rs1811399, and the C allele of rs1234747 may contribute to autism by affecting microRNA rs1861972(A) + rs1861973(C) haplotype assoc. with protective effect against autism in a study of 818 Han Chinese (184 diag. autistics, 225 unrelated volunteers, 409 randomly selected)

Source and license

Adapted from rs1861973 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.