rs189798

A SNP on chromosome 8. Its most notable genotype is A;A: decreased high myopia risk

Gene
None listed
Location
Chr 89,133,067 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GNot ratednormal high myopia riskWorth knowing · 2.040% of people
  2. A;GGooddecreased high myopia riskWorth knowing · 2.040% of people
  3. A;AMost notableGooddecreased high myopia riskWorth knowing · 2.121% of people

SNPedia records rs189798 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 40% A;G 40% A;A 21%
  • European ancestry (Utah)G;G 59% A;G 34% A;A 7%
  • Han Chinese (Beijing)G;G 12% A;G 39% A;A 48%
  • Japanese (Tokyo)G;G 15% A;G 47% A;A 38%
  • Yoruba (Nigeria)G;G 61% A;G 35% A;A 4%
  • African ancestry (Southwest US)G;G 60% A;G 35% A;A 5%
  • Chinese (Denver)G;G 17% A;G 38% A;A 46%
  • Gujarati IndianG;G 30% A;G 52% A;A 19%
  • Luhya (Kenya)G;G 53% A;G 39% A;A 8%
  • Mexican ancestry (Los Angeles)G;G 26% A;G 40% A;A 35%
  • Maasai (Kenya)G;G 63% A;G 33% A;A 4%
  • TuscanG;G 40% A;G 47% A;A 13%

Conditions, medicines and genes

Notes

From SNPedia

Notes

G;G

Normal (higher) risk of high myopia (in French people).(table)

A;G

Less risk of high myopia (in French people). 34.2% of French people without high myopia have T here, but only 21.1% of controls do.(table)

A;A

Less risk of high myopia (in French people). 34.2% of French people without high myopia have T here, but only 21.1% of controls do.(table)

References

Source and license

Adapted from rs189798 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.