rs193922393
A SNP in the STAR gene on chromosome 8. Its most notable genotype is -;-: Lipoid congenital adrenal hyperplasia (LCAH); treatment required
- Gene
- STAR
- Location
- Chr 838,148,684 (GRCh38)
- Highest magnitude
- 9.1Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Most notableBadLipoid congenital adrenal hyperplasia (LCAH); treatment required
- -;ABadCarrier of a mutation for lipoid congenital adrenal hyperplasia (LCAH)
- A;AGoodcommon in clinvar
SNPedia records rs193922393 on the minus strand: (-;-), (-;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other STAR SNPs
- rs104894085A;ALipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs104894086T;TLipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs104894087T;TLipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs104894089T;TLipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs104894090A;ALipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs137852689G;GLipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs137852690A;ALipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
- rs387907235A;ALipoid congenital adrenal hyperplasia (LCAH); treatment requiredVery important
Notes
From SNPedia
Notes
Spontaneous feminization in a 46,XX female patient with congenital lipoid adrenal hyperplasia due to a homozygous frameshift mutation in the steroidogenic acute regulatory protein. Congenital adrenal hyperplasia: molecular genetics and alternative approaches to treatment.
-;-
Lipoid congenital adrenal hyperplasia (LCAH) is considered to be potentially life-threatening unless treated in early infancy; see links at STAR gene and via ClinVar.
-;A
Unaffected in absence of a second mutation in the STAR gene; see STAR gene for discussion and ClinVar links.
Source and license
Adapted from rs193922393 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.