rs1954787

A SNP in the GRIK4 gene on chromosome 11. Its most notable genotype is T;T: ~10% less likely to respond to citalopram

Gene
GRIK4
Location
Chr 11120,792,654 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot rated~10% more likely to respond to citalopramTypical · 0.032% of people
  2. C;TNot ratednormal riskTypical · 0.033% of people
  3. T;TMost notableNot rated~10% less likely to respond to citalopramWorth knowing · 2.035% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 32% C;T 33% T;T 35%
  • European ancestry (Utah)C;C 24% C;T 55% T;T 21%
  • Han Chinese (Beijing)C;C 62% C;T 33% T;T 5%
  • Japanese (Tokyo)C;C 89% C;T 12% T;T 0%
  • Yoruba (Nigeria)C;C <1% C;T 12% T;T 88%
  • African ancestry (Southwest US)C;C 4% C;T 30% T;T 67%
  • Chinese (Denver)C;C 64% C;T 33% T;T 3%
  • Gujarati IndianC;C 27% C;T 48% T;T 26%
  • Luhya (Kenya)C;C 4% C;T 19% T;T 77%
  • Mexican ancestry (Los Angeles)C;C 43% C;T 43% T;T 14%
  • Maasai (Kenya)C;C 6% C;T 33% T;T 60%
  • TuscanC;C 28% C;T 51% T;T 21%

Conditions, medicines and genes

Other GRIK4 SNPs

All GRIK4 SNPs

Notes

From SNPedia

Notes

rs1954787, located in an intron of the GRIK4 gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. From the abstract of this article: "The effect size of (this) GRIK4 marker alone was modest, but homozygote carriers of the treatment-response-associated marker alleles of both the GRIK4 and HTR2A (see rs7997012) genes were 23% less likely to experience nonresponse to (citalopram) treatment relative to participants who did not carry any of these marker alleles." * See also Anxiety Blog posting

Source and license

Adapted from rs1954787 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.