rs1975197

A SNP in the PTPRD gene on chromosome 9. Its most notable genotype is A;A: >1.3x increased risk of developing restless legs syndrome

Gene
PTPRD
Location
Chr 98,846,955 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodNormal risk of developing restless legs syndromeMinor · 1.063% of people
  2. A;GBad1.3x increased risk of developing restless legs syndromeMinor · 1.532% of people
  3. C;CNot ratedNo summary available.Typical · 0.00% of people
  4. A;AMost notableBad>1.3x increased risk of developing restless legs syndromeWorth knowing · 2.05% of people

SNPedia records rs1975197 on the minus strand: (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 63% A;G 32% C;C 0% A;A 5%
  • European ancestry (Utah)G;G 66% A;G 29% C;C 0% A;A 4%
  • Han Chinese (Beijing)G;G 48% A;G 36% C;C 0% A;A 16%
  • Japanese (Tokyo)G;G 49% A;G 42% C;C 0% A;A 10%
  • Yoruba (Nigeria)G;G 87% A;G 13% C;C 0% A;A 0%
  • African ancestry (Southwest US)G;G 68% A;G 32% C;C 0% A;A 0%
  • Chinese (Denver)G;G 39% A;G 54% C;C 0% A;A 7%
  • Gujarati IndianG;G 67% A;G 25% C;C 0% A;A 8%
  • Luhya (Kenya)G;G 81% A;G 19% C;C 0% A;A 0%
  • Mexican ancestry (Los Angeles)G;G 53% A;G 43% C;C 0% A;A 3%
  • Maasai (Kenya)G;G 77% A;G 21% C;C 0% A;A 2%
  • TuscanG;G 61% A;G 37% C;C 0% A;A 2%

Conditions, medicines and genes

Other PTPRD SNPs

All PTPRD SNPs

Notes

From SNPedia

Notes

rs1975197, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs1975197(T) risk allele is 1.31 (CI: 1.20-1.44, adjusted p = 5 x10e-9). Note that a nearby SNP, rs4626664, was also shown to independently confer risk for restless legs syndrome in this same study. Restless Legs Syndrome: Preliminary Research

Source and license

Adapted from rs1975197 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.