rs1983132

A SNP in the LOC105377557 gene on chromosome 4. Its most notable genotype is C;T: 2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos

Gene
LOC105377557
Location
Chr 4177,298,634 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.057% of people
  2. C;TMost notableBad2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofosImportant · 3.035% of people
  3. T;TNot rated2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofosImportant · 3.08% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 57% C;T 35% T;T 8%
  • European ancestry (Utah)C;C 85% C;T 14% T;T <1%
  • Han Chinese (Beijing)C;C 78% C;T 20% T;T 2%
  • Japanese (Tokyo)C;C 72% C;T 26% T;T 3%
  • Yoruba (Nigeria)C;C 20% C;T 57% T;T 22%
  • African ancestry (Southwest US)C;C 33% C;T 53% T;T 14%
  • Chinese (Denver)C;C 75% C;T 24% T;T <1%
  • Gujarati IndianC;C 61% C;T 34% T;T 5%
  • Luhya (Kenya)C;C 33% C;T 51% T;T 16%
  • Mexican ancestry (Los Angeles)C;C 66% C;T 29% T;T 5%
  • Maasai (Kenya)C;C 28% C;T 53% T;T 19%
  • TuscanC;C 75% C;T 22% T;T 4%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs1983132 is a SNP in the NEIL3 gene on ch 4, which encodes a glycosylase that can initiate base excision repair. A study of pesticide use and SNPs in ~800 prostate cancer cases revealed a significant association between men with either a rs1983132(C;T) or (T;T) genotype exposed to the pesticide fonofos and disease risk. The odds ratios and for low and high pesticide use versus no use were 1.65 (CI:0.91-3.01) and 3.25 (CI:1.78-5.92), respectively, whereas fonofos was not associated with prostate cancer risk among men with a rs1983132(C;C) genotype.

Source and license

Adapted from rs1983132 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.