rs1992662

A SNP in the PTGER4 gene on chromosome 5. Its most notable genotype is G;G: increased risk for Crohn's disease

Gene
PTGER4
Location
Chr 540,393,750 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedincreased risk for Crohn's diseaseTypical · 0.034% of people
  2. A;GNot rated?Typical · 0.034% of people
  3. A;ANot rated0.76x decreased risk for Crohn's diseaseTypical · 0.032% of people

SNPedia records rs1992662 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 34% A;G 34% A;A 32%
  • European ancestry (Utah)G;G 9% A;G 46% A;A 45%
  • Han Chinese (Beijing)G;G 58% A;G 27% A;A 16%
  • Japanese (Tokyo)G;G 66% A;G 27% A;A 7%
  • Yoruba (Nigeria)G;G 5% A;G 35% A;A 60%

Conditions, medicines and genes

Other PTGER4 SNPs

All PTGER4 SNPs

Notes

From SNPedia

Notes

rs1992662 is a SNP upstream of the PTGER4 gene that was found in a genome-wide association study to be associated with Crohn's disease. In several European populations, the most common allele, rs1992662(T), was associated with increased risk for Crohn's disease. Conversely, the odds ratio (pooled over several populations) for the minor allele, rs1992662(C), was 0.76 (CI: 0.63-0.91, p=0.0013).

Source and license

Adapted from rs1992662 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.