rs199815268

A SNP in the SGO1-AS1 gene on chromosome 3. Its most notable genotype is C;C: CAID (chronic atrial and intestinal dysrhythmia) predicted

Gene
SGO1-AS1
Location
Chr 320,183,961 (GRCh38)
Highest magnitude
7.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadCAID (chronic atrial and intestinal dysrhythmia) predictedVery important · 7.0
  2. C;TBadCarrier of a CAID mutationImportant · 3.0
  3. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SGO1-AS1 SNPs

All SGO1-AS1 SNPs

Notes

From SNPedia

Show notes, about 130 words

aka c.67A>G (p.Lys23Glu or K23E) rs199815268 represents a rare, recessively inherited variant associated with chronic atrial and intestinal dysrhythmia (CAID). This mutation is identified primarily in the Quebec population and is assumed to have been introduced by a single founder about 900 years ago. A population-scale genealogy model has been developed for this variant based on 3 million married Quebecois, reconstructing the transmission history of the mutation and identifying the most likely early carriers of the mutation. The expected carrier rate is geographically mapped over the region, with the highest carrier rate of 1/155 mapped to Charlevoix and an Quebec-wide estimate of 1/600.

C;C

see text of main rs-page for full details

C;T

see text on main rs-page for details

Source and license

Adapted from rs199815268 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.