rs2003046

A SNP in the C1orf127 gene on chromosome 1. Its most notable genotype is A;A: 0.57x lower risk of Male Pattern Baldness.

Gene
C1orf127
Location
Chr 110,972,770 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.57x lower risk of Male Pattern Baldness.Worth knowing · 2.08% of people
  2. A;CGood0.75x lower risk of Male Pattern Baldness.Worth knowing · 2.038% of people
  3. C;CBadNormal (higher) risk of Male Pattern Baldness.Minor · 1.854% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 8% A;C 38% C;C 54%
  • European ancestry (Utah)A;A 6% A;C 34% C;C 60%
  • Han Chinese (Beijing)A;A 6% A;C 34% C;C 60%
  • Japanese (Tokyo)A;A <1% A;C 27% C;C 73%
  • Yoruba (Nigeria)A;A 12% A;C 41% C;C 48%
  • African ancestry (Southwest US)A;A 12% A;C 47% C;C 40%
  • Chinese (Denver)A;A 6% A;C 39% C;C 56%
  • Gujarati IndianA;A 1% A;C 23% C;C 76%
  • Luhya (Kenya)A;A 21% A;C 49% C;C 30%
  • Mexican ancestry (Los Angeles)A;A 5% A;C 31% C;C 64%
  • Maasai (Kenya)A;A 14% A;C 47% C;C 39%
  • TuscanA;A 6% A;C 43% C;C 51%

Conditions, medicines and genes

Notes

From SNPedia

Notes

This is the 23andMe discovery: "Male Pattern Baldness: Preliminary Research". It affects appearance.

A;A

Discovered by 23andWe based on customer surveys, and considered preliminary research.

A;C

Discovered by 23andMe based on customer surveys, and considered preliminary research.

C;C

Discovered by 23andWe based on customer surveys, and considered preliminary research.

Source and license

Adapted from rs2003046 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.