rs201011613

A SNP in the LOXL1 gene on chromosome 15. Its most notable genotype is A;T: Greatly reduced risk (~25 fold) for exfoliation syndrome

Gene
LOXL1
Location
Chr 1573,946,425 (GRCh38)
Highest magnitude
6.4Very important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.0
  2. A;TMost notableGoodGreatly reduced risk (~25 fold) for exfoliation syndromeVery important · 6.4
  3. T;TGoodGreatly reduced risk (~25 fold) for exfoliation syndromeVery important · 6.4

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other LOXL1 SNPs

All LOXL1 SNPs

Notes

From SNPedia

Notes

rs201011613, also known as Y407F, p.Phe407 and p.Tyr407Phe, is a very rare variant in the LOXL1 gene on chromosome 15. The minor allele is reported to have been seen (at least so far) exclusively in the Japanese population. A large study published in 2017 involving deep resequencing of the entire LOXL1 and CACNA1A genes in 5,570 patients with exfoliation syndrome (XFS) plus 6,279 controls concluded that the rare rs201011613(T) allele provided strong protection against the development of XFS (OR ~25, p = 2.9 × 10e-14).

A;T

see discussion at rs201011613

T;T

see discussion at rs201011613

Source and license

Adapted from rs201011613 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.