rs2011077(C;T)

In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer

Magnitude
0.0Typical
Repute
Bad
Frequency
28%Average of 11 populations
On SNPedia
rs2011077(A;G)Minus strand
Gene
FGFR4

Frequency

Share of people with C;T in each HapMap population.

  • Han Chinese (Beijing)59%
  • Chinese (Denver)49%
  • Japanese (Tokyo)48%
  • Gujarati Indian42%
  • Mexican ancestry (Los Angeles)33%
  • European ancestry (Utah)32%
  • Tuscan26%
  • African ancestry (Southwest US)7%
  • Luhya (Kenya)6%
  • Yoruba (Nigeria)5%
  • Maasai (Kenya)3%

Other genotypes of rs2011077

  1. T;TGoodNormal risk of developing prostate cancer, BPH, and metastatic prostate cancerMinor · 1.010% of people
  2. C;CMost notableBadIn Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancerImportant · 3.062% of people

All about rs2011077

Notes

From SNPedia

For the rs2011077 polymorphism, a significant increased risk of prostate cancer was found in men with the GG genotype (aOR = 6.260, 95% CI = 3.152–12.433, p < 0.001) or the GA genotype (aOR = 2.497, 95% CI = 1.717–3.630, p < 0.001) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of prostate cancer with a gene dosage effect (aOR = 2.500, 95% CI = 1.871–3.339, p < 0.001). As for BPH, a significantly increased risk was found in the GG genotype (aOR = 3.033, 95% CI = 1.352–6.807, p = 0.007) and the GA genotype (aOR = 1.700, 95% CI = 1.077–2.683, p = 0.023) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of BPH with a gene dosage effect (aOR = 1.724, 95% CI = 1.218–2.441, p = 0.002).

Source and license

Adapted from rs2011077(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.