rs2014307
A SNP in the LOC105378525 gene on chromosome 10. Its most notable genotype is T;T: increased risk of age-related macular degeneration
- Gene
- LOC105378525
- Location
- Chr 10122,458,116 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 36%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2014307 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 12%
- European ancestry (Utah)T;T 14%
- Han Chinese (Beijing)T;T 7%
- Japanese (Tokyo)T;T 8%
- Yoruba (Nigeria)T;T 12%
- African ancestry (Southwest US)T;T 7%
- Chinese (Denver)T;T 11%
- Gujarati IndianT;T 15%
- Luhya (Kenya)T;T 7%
- Mexican ancestry (Los Angeles)T;T 21%
- Maasai (Kenya)T;T 3%
- TuscanT;T 22%
Related
Notes
From SNPedia
Notes
news rs572515 was the most significantly associated with AMD risk (P <10-6). rs9288410 and rs2014307 (PLEKHA1/HTRA1) on 10q26 were significantly associated with AMD status (P= .03 and P <10-6 respectively). After controlling for smoking history, gender and age, the most significant gene-gene interaction appears to be between rs10801575 (CFH) and rs2014307 (PLEKHA1/HTRA1) (P <10-11).
Source and license
Adapted from rs2014307 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.