rs2059693

A SNP in the INHA gene on chromosome 2. Its most notable genotype is T;T: 1.6x increased risk for testicular cancer

Gene
INHA
Location
Chr 2219,577,768 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.044% of people
  2. C;TBad1.3x increased risk for testicular cancerMinor · 1.346% of people
  3. T;TMost notableBad1.6x increased risk for testicular cancerMinor · 1.610% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 44% C;T 46% T;T 10%
  • European ancestry (Utah)C;C 54% C;T 39% T;T 7%
  • Han Chinese (Beijing)C;C 52% C;T 41% T;T 7%
  • Japanese (Tokyo)C;C 51% C;T 41% T;T 8%
  • Yoruba (Nigeria)C;C 35% C;T 48% T;T 17%
  • African ancestry (Southwest US)C;C 33% C;T 53% T;T 14%
  • Chinese (Denver)C;C 59% C;T 37% T;T 5%
  • Gujarati IndianC;C 20% C;T 62% T;T 18%
  • Luhya (Kenya)C;C 39% C;T 54% T;T 7%
  • Mexican ancestry (Los Angeles)C;C 41% C;T 48% T;T 10%
  • Maasai (Kenya)C;C 57% C;T 34% T;T 9%
  • TuscanC;C 43% C;T 46% T;T 11%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A study of 577 cases of testicular germ cell tumors, the most common testicular cancer in young men, concluded that the rs2059693(T) allele increased risk. Among Caucasians, the odds ratio for the rs2059693(C;T) genotype was 1.33 (CI: 1.04-1.71), and for the (T;T) genotype, 1.60 (CI: 1.01-2.52, p(trend) = 0.008). The association with rs2059693 was even stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; (C;T) odds ratio 1.63, CI: 0.89-2.99; (T;T) odds ratio 4.54, CI: 2.00-10.3, p(trend) = 0.0008).

Source and license

Adapted from rs2059693 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.