rs2070874

A SNP in the IL4 gene on chromosome 5. Its most notable genotype is C;C.

Gene
IL4
Location
Chr 5132,674,018 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.038% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 38%
  • European ancestry (Utah)C;C 74%
  • Han Chinese (Beijing)C;C 5%
  • Japanese (Tokyo)C;C 7%
  • Yoruba (Nigeria)C;C 27%
  • African ancestry (Southwest US)C;C 39%
  • Chinese (Denver)C;C 6%
  • Gujarati IndianC;C 78%
  • Luhya (Kenya)C;C 18%
  • Mexican ancestry (Los Angeles)C;C 38%
  • Maasai (Kenya)C;C 48%
  • TuscanC;C 77%

Conditions, medicines and genes

Other IL4 SNPs

All IL4 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs2070874 is a SNP in the promoter region of the interleukin 4 IL4 gene. This SNP is one of five SNPs reported to be useful in a SNP set defining the risk of dying from prostate cancer among patients with the disease; see gs242 and gs243. Visceral leishmaniasis (VL) caused by Leishmania chagasi is endemic to northeast Brazil. A positive delayed-type hypersensitivity skin test response (DTH+) is a marker for acquired resistance to disease. the DTH- phenotype was associated with SNP rs2070874 at IL4 (OR 3.14; P=0.006; 95% CI=1.38-7.14), and SNP rs30740 between LECT2 and TGFBI (OR 3.00; P=0.042; 95% CI=1.04-8.65)

Source and license

Adapted from rs2070874 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.