rs2075291

A SNP in the ZPR1 gene on chromosome 11. Its most notable genotype is C;C: normal

Gene
ZPR1
Location
Chr 11116,790,676 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormalTypical · 0.096% of people
  2. A;CNot rated4x higher risk for high triglyceride levels in AsiansTypical · 0.04% of people
  3. A;ANot rated>4x higher risk for high triglyceride levels in AsiansTypical · 0.00% of people

SNPedia records rs2075291 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 96% A;C 4% A;A 0%
  • European ancestry (Utah)C;C 97% A;C 3% A;A 0%
  • Han Chinese (Beijing)C;C 91% A;C 9% A;A 0%
  • Japanese (Tokyo)C;C 92% A;C 8% A;A 0%
  • Yoruba (Nigeria)C;C 99% A;C 1% A;A 0%
  • Chinese (Denver)C;C 90% A;C 10% A;A 0%
  • Gujarati IndianC;C 99% A;C 1% A;A 0%
  • Luhya (Kenya)C;C 99% A;C <1% A;A 0%
  • Mexican ancestry (Los Angeles)C;C 98% A;C 2% A;A 0%

Conditions, medicines and genes

Other ZPR1 SNPs

All ZPR1 SNPs

Notes

From SNPedia

Notes

SNP rs2075291 represents a glycine to cysteine substitution at amino acid 185 of the APOA5 protein; it is also known as p.185Gly>Cys or c.553G>T. In both Chinese and non-Chinese Asians, the A allele (leading to the cysteine) is associated with higher risk for hypertriglyceridemia. The odds ratio is 4.45 (CI: 2.18-9.07, p<0.001). Heterozygosity was associated with a doubling of triglyceride levels, and all (11) rs2075291(A;A) homozygotes (as oriented relative to dbSNP, not as published) had severe hypertriglyceridemia (mean triglyceride level of 2292 +/- 447 mg/dl).

Source and license

Adapted from rs2075291 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.