rs2108622

A SNP in the CYP4F2 gene on chromosome 19. Its most notable genotype is C;C: lower warfarin dosing

Gene
CYP4F2
Location
Chr 1915,879,621 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedlower warfarin dosingWorth knowing · 2.063% of people
  2. C;TNot ratedNo summary available.Typical · 0.032% of people
  3. T;TNot ratedhigher warfarin dosingWorth knowing · 2.06% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 63% C;T 32% T;T 6%
  • European ancestry (Utah)C;C 61% C;T 32% T;T 7%
  • Han Chinese (Beijing)C;C 59% C;T 39% T;T 2%
  • Japanese (Tokyo)C;C 63% C;T 27% T;T 10%
  • Yoruba (Nigeria)C;C 91% C;T 9% T;T <1%
  • African ancestry (Southwest US)C;C 81% C;T 19% T;T 0%
  • Chinese (Denver)C;C 55% C;T 40% T;T 5%
  • Gujarati IndianC;C 31% C;T 51% T;T 19%
  • Luhya (Kenya)C;C 82% C;T 17% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 56% C;T 42% T;T 2%
  • Maasai (Kenya)C;C 63% C;T 35% T;T 3%
  • TuscanC;C 47% C;T 38% T;T 15%

Conditions, medicines and genes

Other CYP4F2 SNPs

All CYP4F2 SNPs

Notes

From SNPedia

Notes

rs2108622 is a SNP in the cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F2 gene. In the males rs2108622(G) was significantly higher in cerebral infarction patients (P = 0.025) A study of Italian patients concluded that rs2108622(T;T) patients require 5.49 mg/day of warfarin versus 2.93 mg/day for (C;C) patients. Analysis of variance indicates that about 7% of mean weekly warfarin dose variance is explained by CYP4F2 genotype. A study of 370 Brazilian ("admixed") patients concludes that prospective CYP4F2 genotyping is of little value to these patients, presumably due to ethnic-based differences.

Source and license

Adapted from rs2108622 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.