rs2149954

A SNP in the LOC101927697 gene on chromosome 5. Its most notable genotype is T;T: slight association with longer life (longevity)

Gene
LOC101927697
Location
Chr 5158,393,594 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodslight association with longer life (longevity)Minor · 1.211% of people
  2. C;TGoodslight association with longer life (longevity)Minor · 1.143% of people
  3. C;CGoodcommon/normalTypical · 0.047% of people

SNPedia records rs2149954 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 11% C;T 43% C;C 47%
  • European ancestry (Utah)T;T 11% C;T 43% C;C 46%
  • Han Chinese (Beijing)T;T 3% C;T 31% C;C 66%
  • Japanese (Tokyo)T;T 2% C;T 20% C;C 79%
  • Yoruba (Nigeria)T;T 18% C;T 42% C;C 41%
  • African ancestry (Southwest US)T;T 9% C;T 53% C;C 39%
  • Chinese (Denver)T;T 4% C;T 42% C;C 54%
  • Gujarati IndianT;T 14% C;T 51% C;C 36%
  • Luhya (Kenya)T;T 20% C;T 45% C;C 36%
  • Mexican ancestry (Los Angeles)T;T 2% C;T 39% C;C 60%
  • Maasai (Kenya)T;T 21% C;T 56% C;C 22%
  • TuscanT;T 14% C;T 49% C;C 37%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A genome-wide association meta-analysis of 7,729 long-lived individuals of European descent (≥ 85 years) and 16,121 younger controls (<65 years), followed by replication in an additional set of 13,060 long-lived individuals and 61,156 controls, found a (slight) association with longevity, as reflected by survival to ages beyond 90 years, for rs2149954, (OR 1.10, p = 1.74 × 10e-8). The less common rs2149954(A) allele (as represented in dbSNP orientation) is associated with low blood pressure in middle age and decreased cardiovascular mortality risk (independent of blood pressure).

T;T

see rs2149954

C;T

see rs2149954

Source and license

Adapted from rs2149954 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.