rs2165870
A SNP in the CHRM3 gene on chromosome 1. Its most notable genotype is A;A: 2x higher risk for post-operative nausea
- Gene
- CHRM3
- Location
- Chr 1239,622,120 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- Not on consumer chips
- Minor allele frequency
- 24%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot rated2x higher risk for post-operative nausea
- A;GNot rated2x higher risk for post-operative nausea
- G;GNot ratedNo summary available.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 6% A;G 28% G;G 66%
- European ancestry (Utah)A;A 11% A;G 37% G;G 52%
- Han Chinese (Beijing)A;A 4% A;G 31% G;G 64%
- Japanese (Tokyo)A;A 7% A;G 46% G;G 48%
- Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
Related
Notes
From SNPedia
Notes
rs2165870 is a SNP in or near the promoter region of the muscarinic acetylcholine receptor 3 subtype CHRM3 gene on ch 1. A GWAS study of 300+ patients exhibiting post-operative nausea found that carriers of rs2165870(A) alleles were at 2.3x higher risk for nausea (CI: 1.36 - 4, p = 0.002). rs2355230 is said to be a perfect proxy (r2 = 1) for rs2165870.
Source and license
Adapted from rs2165870 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.