rs2188380

A SNP on chromosome 12. Its most notable genotype is T;T: slightly higher risk for gout

Gene
None listed
Location
Chr 12110,948,323 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadslightly higher risk for goutWorth knowing · 2.0100% of people
  2. C;TBadslightly higher risk for goutMinor · 1.80% of people
  3. C;CGoodlower risk for goutWorth knowing · 2.00% of people

SNPedia records rs2188380 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 2 HapMap populations.

  • AverageT;T 100% C;T 0% C;C 0%
  • European ancestry (Utah)T;T 100% C;T 0% C;C 0%
  • Yoruba (Nigeria)T;T 100% C;T 0% C;C 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

gout association, based on ; note that this publication refers to risk allele (T) based on the minus strand, whereas for dbSNP and SNPedia, rs72552713 is defined as on the plus strand, so therefore the risk allele is (A).

T;T

Over half of the people in any population have this genotype, which is reported to be at slightly higher risk (>2x) for gout compared to people who have zero (A) alleles for this SNP.

Source and license

Adapted from rs2188380 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.