rs2207418

A SNP on chromosome 20. Its most notable genotype is G;G: ~2x increased risk of heart failure, at least in Amish

Gene
None listed
Location
Chr 2011,194,255 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated~2x increased risk of heart failure, at least in AmishWorth knowing · 2.016% of people
  2. A;GNot rated1.5x increased risk for heart failure, at least in AmishMinor · 1.536% of people
  3. A;ANot ratedNo summary available.Typical · 0.048% of people

SNPedia records rs2207418 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 16% A;G 36% A;A 48%
  • European ancestry (Utah)G;G 9% A;G 37% A;A 54%
  • Han Chinese (Beijing)G;G 42% A;G 42% A;A 15%
  • Japanese (Tokyo)G;G 35% A;G 44% A;A 21%
  • Yoruba (Nigeria)G;G 6% A;G 27% A;A 67%
  • African ancestry (Southwest US)G;G 2% A;G 37% A;A 61%
  • Chinese (Denver)G;G 38% A;G 51% A;A 11%
  • Gujarati IndianG;G 9% A;G 40% A;A 52%
  • Luhya (Kenya)G;G <1% A;G 20% A;A 79%
  • Mexican ancestry (Los Angeles)G;G 28% A;G 41% A;A 31%
  • Maasai (Kenya)G;G 1% A;G 14% A;A 85%
  • TuscanG;G 7% A;G 37% A;A 56%

Notes

From SNPedia

Notes

rs2207418 is a SNP located in a 'gene desert' region of ch 20p12. In an Amish founder population of 851 individuals, the rs2207418(C) allele was associated with cardiac hypertrophy, increased risk of heart failure (relative risk 1.85, CI: 1.2 - 2.7, p = 0.0019), and increased mortality (hazard risk 1.5, CI: 1.2 - 1.9, p = 0.0004).

Source and license

Adapted from rs2207418 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.