rs2224391

A SNP in the LYRM4 gene on chromosome 6. Its most notable genotype is A;A: common in clinvar

Gene
LYRM4
Location
Chr 65,260,703 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.038% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 38%
  • European ancestry (Utah)A;A 57%
  • Han Chinese (Beijing)A;A 50%
  • Japanese (Tokyo)A;A 62%
  • Yoruba (Nigeria)A;A 0%
  • African ancestry (Southwest US)A;A 7%
  • Chinese (Denver)A;A 61%
  • Gujarati IndianA;A 71%
  • Luhya (Kenya)A;A 2%
  • Mexican ancestry (Los Angeles)A;A 44%
  • Maasai (Kenya)A;A 8%
  • TuscanA;A 61%

Notes

From SNPedia

Notes

Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia.

Source and license

Adapted from rs2224391 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.