rs2227928

A SNP in the ATR gene on chromosome 3. Its most notable genotype is G;G: poorer response to pancreatic cancer combined treatment

Gene
ATR
Location
Chr 3142,562,770 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadpoorer response to pancreatic cancer combined treatmentTypical · 0.041% of people
  2. A;GBadpoorer response to pancreatic cancer combined treatmentTypical · 0.044% of people
  3. A;AGoodnormalTypical · 0.015% of people

SNPedia records rs2227928 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 41% A;G 44% A;A 15%
  • European ancestry (Utah)G;G 24% A;G 58% A;A 19%
  • Han Chinese (Beijing)G;G 33% A;G 42% A;A 26%
  • Japanese (Tokyo)G;G 19% A;G 55% A;A 26%
  • Yoruba (Nigeria)G;G 77% A;G 22% A;A 1%
  • African ancestry (Southwest US)G;G 61% A;G 30% A;A 9%
  • Chinese (Denver)G;G 17% A;G 54% A;A 29%
  • Gujarati IndianG;G 16% A;G 58% A;A 26%
  • Luhya (Kenya)G;G 75% A;G 21% A;A 4%
  • Mexican ancestry (Los Angeles)G;G 21% A;G 64% A;A 16%
  • Maasai (Kenya)G;G 67% A;G 29% A;A 4%
  • TuscanG;G 37% A;G 55% A;A 8%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2227928, also known as Ex4+340C>T or T211M, is a SNP in the ATR gene. Although not significant on it's own, as 1 of 3 SNPs its risk allele (rs2227928(C)) is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy. Median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004).

Source and license

Adapted from rs2227928 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.