rs2228152
A SNP in the F8 gene on chromosome X. Its most notable genotype is A;A: Hemophilia A (severity varies)
- Gene
- F8
- Location
- Chr X154,931,407 (GRCh38)
- Highest magnitude
- 5.5Very important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- A;TBadCarrier of a Hemophilia A mutation
- A;AMost notableBadHemophilia A (severity varies)
SNPedia records rs2228152 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in one HapMap population.
- European ancestry (Utah)T;T 100% A;T 0% A;A 0%
Related
Other F8 SNPs
- rs28933668T;THemophilia A (severity varies)Very important
- rs28933669G;GHemophilia A (severity varies)Very important
- rs28933670C;CHemophilia A (severity varies)Very important
- rs28933671C;CHemophilia A (severity varies)Very important
- rs28933672A;AHemophilia A (severity varies)Very important
- rs28933674T;THemophilia A (severity varies)Very important
- rs28933675A;AHemophilia A (severity varies)Very important
- rs28933676G;GHemophilia A (severity varies)Very important
Notes
From SNPedia
Notes
A;T
X-linked recessive, so females are generally unaffected in the absence of a second F8 gene mutation, however some females may experience clotting issues.
Source and license
Adapted from rs2228152 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.