rs2228314

A SNP in the SREBF2 gene on chromosome 22. Its most notable genotype is C;C: 2.03x risk of osteoarthritis

Gene
SREBF2
Location
Chr 2241,880,738 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad2.03x risk of osteoarthritisWorth knowing · 2.015% of people
  2. C;GBad1.48x risk of osteoarthritisMinor · 1.446% of people
  3. G;GNot ratedNo increased risk of osteoarthritisMinor · 1.039% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 15% C;G 46% G;G 39%
  • European ancestry (Utah)C;C 5% C;G 45% G;G 51%
  • Han Chinese (Beijing)C;C 7% C;G 32% G;G 61%
  • Japanese (Tokyo)C;C 9% C;G 57% G;G 34%
  • Yoruba (Nigeria)C;C 38% C;G 51% G;G 11%

Other SREBF2 SNPs

All SREBF2 SNPs

Notes

From SNPedia

Notes

. Heterozygous odds ratio 1.481 (1.201–1.827) p<0.001; Homozygous minor odds ratio 2.038 (0.693–5.992) p = 0.187

Source and license

Adapted from rs2228314 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.