rs2228325

A SNP in the ACTN3 gene on chromosome 11. Its most notable genotype is T;T: impaired muscle performance

Gene
ACTN3
Location
Chr 1166,560,624 (GRCh38)
Highest magnitude
2.3Worth knowing
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedbetter performing musclesWorth knowing · 2.142% of people
  2. C;TNot ratedmixed muscle typesWorth knowing · 2.143% of people
  3. T;TMost notableNot ratedimpaired muscle performanceWorth knowing · 2.314% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 42% C;T 43% T;T 14%
  • European ancestry (Utah)C;C 20% C;T 58% T;T 22%
  • Han Chinese (Beijing)C;C 34% C;T 45% T;T 20%
  • Japanese (Tokyo)C;C 20% C;T 62% T;T 18%
  • Yoruba (Nigeria)C;C 80% C;T 20% T;T 0%
  • African ancestry (Southwest US)C;C 63% C;T 37% T;T 0%
  • Chinese (Denver)C;C 39% C;T 39% T;T 21%
  • Gujarati IndianC;C 13% C;T 58% T;T 29%
  • Luhya (Kenya)C;C 86% C;T 14% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 16% C;T 59% T;T 26%
  • Maasai (Kenya)C;C 65% C;T 31% T;T 5%
  • TuscanC;C 28% C;T 54% T;T 18%

Other ACTN3 SNPs

All ACTN3 SNPs

Notes

From SNPedia

Notes

Merged into rs1815739

C;C

An older name for rs1815739, this genotype indicates better performing muscles

C;T

An older name for rs1815739, this genotype indicates some of a lower performing muscle type

T;T

An older name for rs1815739, this genotype indicates impaired muscle performance

References

Source and license

Adapted from rs2228325 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.