rs2228576

A SNP in the SCNN1A gene on chromosome 12. Its most notable genotype is T;T: common in clinvar

Gene
SCNN1A
Location
Chr 126,347,896 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodcommon in clinvarTypical · 0.09% of people

SNPedia records rs2228576 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 9%
  • European ancestry (Utah)T;T 6%
  • Han Chinese (Beijing)T;T 13%
  • Japanese (Tokyo)T;T 18%
  • Yoruba (Nigeria)T;T 0%

Other SCNN1A SNPs

All SCNN1A SNPs

Notes

From SNPedia

Notes

New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. A candidate gene association study of 77 polymorphisms in migraine.

Source and license

Adapted from rs2228576 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.